any people Mwho take the prescription drug hydrocodone want to know what will happen if they take it with alcohol. It is well known that medication should not be mixed with alcohol, as the results can be fatal. In the case of Hydrocodone, it depresses the central nervous system. Alcohol has the same effect and when depression of the central nervous system occurs then side effects like reduced breathing, unconsciousness and a slow heart rate will all occur. Death is highly possible and it is for that reason that hydrocodone should not be mixed with alcohol.